PhenX RISING

PhenX RISING (Real world, Implementation, SharingING) was a group of seven investigators funded by National Human Genome Research Institute (NHGRI) and the Office of Behavioral and Social Sciences Research (OBSSR) to incorporate PhenX measures into ongoing studies. Between 2011 and 2012, these researchers selected and evaluated PhenX measures for use in their own research and recommended improvements to the PhenX Toolkit.

Among the seven groups, 76 PhenX measures were added to existing studies. The measures added included demographics, psychosocial risk factors, psychiatric assessments, and a variety of exposures. Each group added between 4 and 37 measures with five groups adding more than 20 measures. In all, 55 of the 76 measures were shared by two or more groups, providing common ground for future cross-study analysis.

PhenX RISING provided a cross-section of different study designs, populations, and topics, including single site studies, multi-center studies, genetics consortia, and biobanks. They include studies of children as young as three years old through adolescence and adulthood, as well as one with a large population of centenarians. The projects addressed the role of genes and environment in psychopathology and behavior, neuro-imaging and genomics; the determinants of longevity, and the genetics of conditions such as diabetes, cataracts, and high cholesterol.

 The seven studies funded under PhenX RISING (NOT-HG-11-009) were:

PI / Institution

Study Name

Funding Agency

Allison Aiello, PhD, 

University of Michigan, Ann Arbor

 

Ecologic Stressors, Post-Traumatic Stress Disorder, and Drug Use in Detroit
 

National Institute on Drug Abuse

Robert Bilder, PhD (Co-Chair),

University of California, Los Angeles  
 

Human Translational Applications Core

National Institute of Mental Health

Terry Jernigan, PhD,

University of California, San Diego
 

Creating a Pediatric Imaging-Genomics Data Resource

National Institute on Drug Abuse

Catherine McCarty, PhD, (Co-Chair),

Essentia Institute of Rural Health

Genome-Wide Study of Cataract and Low HDL in Personalized Medicine Research Project

National Human Genome Research Institute

Dharambir Sanghera, PhD,

University of Oklahoma, Oklahoma City

Genome-Wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian Indians

National Institute of Diabetes and Digestive and Kidney Diseases

Timothy Strauman, PhD, and Ahmad  Hariri, PhD,

Duke University

Self-Regulation Failure: Identifying and Modifying a Risk Phenotype

National Institute on Drug Abuse

Yi Zeng, PhD,

Duke University

Determinants of Healthy Longevity in China
 

National Institute on Aging

 
Information and materials about PhenX are posted at www.phenx.org or www.phenxtoolkit.org