PhenX Expert Review Panel Roles and Responsibilities

Expert Review Panels (ERPs) have been established to review and update the domain measures in the PhenX Toolkit. Each ERP is responsible for reviewing one domain, or a cluster of domains. ERPs enhance the content (e.g. adding keywords and new references) and recommend retiring or adding new measures.  Each ERP is composed of at least one former PhenX Working Group (WG) Member and one or more experts with relevant experience. One ERP member will be designated as the ERP Lead, who will drive the consensus process and present the ERP’s recommendations to the PhenX SC.  An SC Member will serve as a Liaison to each ERP and an ERP manager and supervisor will support each panel.  The ERP domains were prioritized by the SC as shown below:

  1. Anthropometrics, Physical Activity and Physical Fitness, Nutrition and Dietary Supplements, Diabetes (Completed October 1, 2015)

  2. Demographics, Environmental Exposures, Social Environments (Completed May 31, 2016)

  3. Substance Abuse and Addiction, Alcohol, Tobacco and Other Substances (Completed November 21, 2016)

  4. Psychiatric, Neurology, Psychosocial (Completed November 28, 2017)

  5. Respiratory (Completed November 28, 2017)

  6. Speech and Hearing

  7. Cancer

  8. Gastrointestinal

  9. Infectious Diseases and Immunity

Roles of the Expert Review Panels

  • Make recommendations to keep, update, retire, or replace each measure under the purview of the ERP.
  • Consider the responses from the community outreach effort.
  • Document the measures considered, the rationale for inclusion or exclusion, and any identified gaps.

Responsibilities of the Expert Review Panels

  • Review Existing Measures
  • Review existing measures based on guidance from the SC.
  • Determine if a measure needs to be revised or replaced based on new scientific findings.
  • Identify other measures and protocols that might complement those currently in the PhenX Toolkit.
  • Identify errors in the Toolkit to be fixed immediately.
  • Recommend proposed changes to the SC.
  • Communication
  • Consider ways to promote the updates through presentations, publications and other communications with the scientific community.
  • Encourage colleagues to use the measures in the PhenX Toolkit.


Month 1                 Participate in an introductory conference call.

Month 2-3              Determine which measures should be retained as-is, updated, replaced or retired, and make appropriate updates in

                             preparation for outreach.   

Month 4                 Conduct outreach with the scientific community to get feedback on the recommended changes.  Hold meeting with the

                             ERP to discuss feedback.

Month 5                 Provide the SC with all the recommended changes to measures.  Prepare updates to be released into PhenX Toolkit.


PhenX Senior Management Team

RTI International                                                             NHGRI

Carol M. Hamilton, Ph.D., Principal Investigator                                Erin Ramos, Ph.D., M.P.H., Project Scientist

Tabitha Hendershot, Co-Investigator                                                 Teri Manolio, M.D., Ph.D., 

Deborah Maiese, M.P.A., Consensus Coordinator                                Director Office of Population Genomics

Amanda Riley, M.B.A., Project Manager                                             Senior Advisor to the Director, NHGRI, for

                                                                                                       Population Genomics


Information and materials about PhenX are posted at or