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PhenX Administrative Supplements 


Background


In early 2011, PhenX, led by RTI International and funded by the National Human Genome Research Institute (NHGRI), received an administrative supplement from the National Institute on Drug Abuse (NIDA) to expand the depth and breadth of Substance Abuse and Addiction (SAA) measures in the PhenX Toolkit.  Since that time, other administrative supplements have been awarded and sponsored by the U.S. Food and Drug Administration (FDA) and NIH Tobacco Regulatory Science Program (TRSP), the National Institute of Mental Health (NIMH), and the National Heart, Lung and Blood Institute (NHLBI).

PhenX Substance Abuse and Addiction (SAA) Project

In 2011, NIDA sponsored an administrative supplement to expand the depth and breadth of measures related to substance abuse and addiction (SAA) in the PhenX Toolkit.  An SAA Scientific Panel (SSP), chaired by Dr. Kenneth Sher, provided guidance to the SAA Working Groups (WG).  The SAA measures were selected by the SAA WGs using a streamlined version of the established consensus process.  The SAA measures are presented in the Toolkit as one Core collection and six Specialty Collections.

PhenX Measures for Mental Health Research

In 2014, the NIMH sponsored an administrative supplement to add several Specialty collections (Suicide, PTSD, and Eating Disorders) and one Core collection to the Toolkit.  The eight-member Mental Health Research Panel (MHRP), co-chaired by Drs. Deanna Barch and Ian Gotlib, will guide the selection of these high-quality measures for inclusion into the PhenX Toolkit to help establish a common currency to better understand the etiology, progression, and treatment of these mental health conditions.

PhenX Measures for Tobacco Regulatory Research

In 2014, the FDA and NIH-TRSP sponsored an administrative supplement to add tobacco-related measures to the Toolkit and enhance cross-study analysis in large-scale research.  The nine-member Tobacco Regulatory Research Panel (TRRP), co-chaired by Drs. Jodi Prochaska and Gary Swan, will add five Specialty collections based on the HAVE (Host-Social/Cognitive, Host-Biobehavioral, Agent, Vector, and Environment) framework, as well as one Core collection of tobacco regulatory research measures to the Toolkit.

PhenX Measures for Sickle Cell Disease Research

In 2014, the NHBLI sponsored an administrative  supplement to identify standard measures related to Sickle Cell Disease (SCD) for inclusion in the PhenX Toolkit.  The proposed measures will be organized into two Specialty collections and a Core collection of measures that are broadly relevant to all SCD researchers and clinicians. To facilitate data sharing and interoperability, measures that are released in the Toolkit are associated with several types of standards, including Common Data Elements (CDEs). 

PhenX Senior Management Team

RTI International    

Carol M. Hamilton, Ph.D., Principal Investigator          
 

Deborah Maiese, M.P.A., Consensus Coordinator
 

Tabitha Hendershot, Co-Investigator
 

Amanda Riley, P.M.P., Project Manager

NHGRI

Erin Ramos, Ph.D., M.P.H., Project                           
 

Teri Manolio, M.D., Ph.D., Director, Division of Genomic Medicine


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