Protocol - Rheumatic Fever/Rheumatic Heart Disease

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Measure to assess history of Rheumatic Fever or Rheumatic Heart Disease.

Specific Instructions

Ask question 1, and if "yes," proceed to ask questions 2, 3, and 4.




1. Has a doctor ever said you had rheumatic fever (inflammatory rheumatism)?

[ ] Yes

[ ] No

If Yes

2. Have you had it in the past 12 months?

[ ] Yes

[ ] No

[ ] Dont Know

3. Are you taking any pills or medicine for it?

[ ] Yes

[ ] No

If Yes

4. What is it? ____________________________________________________

Personnel and Training Required

An interviewer who is trained to conduct personal interviews with individuals from the general population is required. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews.* The interviewer should be trained to prompt respondents further if a "dont know" response is provided.

*There are multiple modes to administer this question (e.g., paper-and-pencil and computer-assisted interviews).

Equipment Needs


Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Interviewer-administered questionnaire


Adolescent, Adult


12–17-year-olds with parent/guardian consent or parent/guardian as surrogate

Note: This protocol has been reliably used with ages 12–17 years. However, the Cardiovascular Working Group suggests the same methodology can be used for ages 12 years and over.

Selection Rationale

This protocol was selected because it collects a personal history of the disease, as well as information about medication usage.


Chinese, English, Other languages available at source

Logical Observation Identifiers Names and Codes (LOINC) Rheumatic fever proto 62403-1 LOINC
Human Phenotype Ontology Fever HP:0001945 HPO
caDSR Form PhenX PX041401 - Rheumatic Fever Rheumatic Heart Disease 5849257 caDSR Form
Derived Variables


Process and Review

Not applicable.

Protocol Name from Source

Health Examination Survey (HES)


Centers for Disease Control and Prevention (CDC). National Center for Health Statistics. Health Examination Survey (HES) I–III. Page 39. Questions 62a–62d (source for questions 1–4).

General References

Diagnostic Criteria:

One or both of two subcategories can be present for diagnosis of rheumatic fever (RF) or rheumatic heart disease (RHD), according to the World Health Organization (WHO) Criteria:

(a) RF: Two major or one major and two minor manifestations plus evidence of a preceding group A streptococcal infection.

  • Major criteria are carditis, polyarthritis, chorea, erythema marginatum, and subcutaneous nodules.
  • Minor manifestations include fever and polyarthralgia; EKG-prolonged PR interval; elevated laboratory evidence of inflammation (erythrocyte sedimentation rate, white blood cell count, C-reactive protein).

(b) Chronic valve lesions of RHD: presentation with pure mitral stenosis or mixed mitral valve disease with or without aortic valve disease. Do not require other criteria for Rheumatic Heart Disease diagnosis.

World Health Organization (WHO). (2004). Rheumatic fever and rheumatic heart disease: Report of a WHO Expert Consultation, Geneva, 29 October–1 November 2001 (WHO Technical Report Series No. 923). Geneva, Switzerland: Author (source for Diagnostic Criteria).

Protocol ID


Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX041401010000 Has a doctor ever said you had rheumatic more
fever (inflammatory rheumatism)? show less
Variable Mapping
PX041401030000 Are you taking any pills or medicine for it? N/A
PX041401040000 What is it? N/A
PX041401020000 Have you had it in the past 12 months? N/A
Measure Name

Rheumatic Fever/Rheumatic Heart Disease

Release Date

September 9, 2009


This measure assesses the respondent's history of rheumatic fever or rheumatic heart disease.


To assess history of Rheumatic Fever or Rheumatic Heart Disease as a determinant of damage to the heart valves and possible risk of heart failure.


Cardiovascular, heart failure, Health Examination Survey, HES, rheumatic fever, rheumatic heart disease, inflammatory rheumatism, valvular dysfunction, personal history

Measure Protocols
Protocol ID Protocol Name
41401 Rheumatic Fever/Rheumatic Heart Disease

There are no publications listed for this protocol.